Insulin-Resistant Cardiomyopathy

Insulin-Resistant Cardiomyopathy

Increasing evidence points to insulin resistance as a primary etiologic factor in the development of nonischemic heart failure (HF). The myocardium normally responds to injury by altering substrate metabolism to increase energy efficiency. Insulin resistance prevents this adaptive response and can lead to further injury by contributing to lipotoxicity, sympathetic up-regulation, inflammation, o...

Insulin Resistance and Cardiomyopathy

Zataria multiflora increases insulin sensitivity and PPARγ gene expression in high fructose fed insulin resistant rats

  Objective(s):In insulin resistance, the insulin action in liver, muscles and adipocytes decreases and result in hyperglycemia, dyslipidemia and hyperinsulinemia. In this study we evaluate the effect of Zataria multiflora extract on insulin sensitivity in high fructose fed insulin resistant rats, since this extract was shown antihyperglycemic effect in streptozotocin induced diabetes in rats. ...

Berberis integerrima ameliorates insulin resistance in high- fructose-fed insulin-resistant rats

Objective(s): This study was aimed to investigate the effect of Berberis integerrima (B. integerrima) extract on insulin sensitivity in high-fructose-fed insulin-resistant rats. Materials and Methods: Experimental rats were randomly divided into two groups: the control group was fed a regular chow diet while other group fed with a high-fructose diet for 8 weeks. After the first six weeks, the a...

[Insulin-dependent. Rapamycin-resistant?].

The development of drug-eluting stents has revolutionized interventional cardiology. In Spain, 25 148 drug-eluting stents were implanted in 2004, according to the Registro Español de Hemodinámica y Cardiología Intervencionista (Spanish Registry of Hemodynamics and Interventional Cardiology).1 Based on the results of key randomized studies with sirolimuseluting2,3 and paclitaxel-eluting stents,4...